JOIN US
The Marasco Lab offers exciting research opportunities in human antibody engineering and regenerative medicine. With our numerous tools including state-of-the-art humanized mouse models, we are making discoveries in B cell development, host immunity and vaccine design for both infectious disease and cancer immunotherapy applications. Our research team focuses on identification of clinically relevant human monoclonal antibodies and studies of their mechanism of action. Our humanized mouse models are also being used to investigate the pluripotency of adult stem cells with applications in the field of regenerative medicine.
Working in Dr. Marasco's laboratory provides exposure to the most recent developments in the field of antibody engineering, cancer immunotherapy, and adult stem cell biology. We are always looking for highly motivated post-doctoral fellows and graduate students to join our research team, particularly those individuals with high intellect who are also creative thinkers.
Applicants should have a strong interest in human translational research. Job openings are posted with DFCI Human Resources. Interested applicants should address their cover letter to:
Wayne A. Marasco, M.D., Ph.D.
Department of Cancer Immunology & Virology
Dana-Farber Cancer Institute
450 Brookline Avenue
Boston, MA 02215
Working in Dr. Marasco's laboratory provides exposure to the most recent developments in the field of antibody engineering, cancer immunotherapy, and adult stem cell biology. We are always looking for highly motivated post-doctoral fellows and graduate students to join our research team, particularly those individuals with high intellect who are also creative thinkers.
Applicants should have a strong interest in human translational research. Job openings are posted with DFCI Human Resources. Interested applicants should address their cover letter to:
Wayne A. Marasco, M.D., Ph.D.
Department of Cancer Immunology & Virology
Dana-Farber Cancer Institute
450 Brookline Avenue
Boston, MA 02215
Current Openings
If you are interested in joining the lab, please send your CV and cover letter to MarascoLab@dfci.harvard.edu.
Research Fellow - Marasco Lab (Job ID: 2022-27231)
Description:
Exciting opportunity for an exceptional post-doc applicant to conduct research on the effects of aging on influenza vaccine responsiveness in an effort to develop durable “Universal Influenza Vaccines”. Dr. Marasco is the Lead PI of this collaborative Harvard Medical School program that will examine T cell, B cell and metabolic aspects of aging (https://marascolab.dana-farber.org/). The project will involve both conceptual and technical innovations with the collaborating labs located within short walking distance from each other. Dr. Marasco’s lab will assess metabolic and population-based changes in B cell populations of young and aged individuals post influenza vaccination, with the aim of testing the paradigm that multiple subsets of antigen-specific B cells are altered in older individuals. Conceptional innovation will be pursued by investigating both germinal center and memory origins of antigen-specific B cells, antigen-specific molecular profiling to explore the effect of immune imprinting to the critical Hemagglutinin (HA) stem epitope(s), and performing simultaneous analysis of all B cell subsets and their binding specificities to different HA epitopes. Technical innovation for this project involves functional studies with the integration of LIBRA-Seq to identify B cell subsets directed to distinct epitopes on the HA head and stem domain.
Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.
Requirements:
The funding available is for an initial appointment over three years and the starting date is flexible. The candidate will be expected to carry out bench research (both independently and as part of a team), participate in group discussions, and write research proposals and manuscripts.
Qualifications:
Those with a strong background in immunology, B cell biology, structural biology, infectious diseases and bench experience in flow cytometry and molecular biology are encouraged to apply. Background knowledge in genomics and a good knowledge of R, python and/or other programming languages is desirable, but not required. Successful candidates should demonstrate a track record of research achievements and have excellent communication skills.
Description:
Exciting opportunity for an exceptional post-doc applicant to conduct research on the effects of aging on influenza vaccine responsiveness in an effort to develop durable “Universal Influenza Vaccines”. Dr. Marasco is the Lead PI of this collaborative Harvard Medical School program that will examine T cell, B cell and metabolic aspects of aging (https://marascolab.dana-farber.org/). The project will involve both conceptual and technical innovations with the collaborating labs located within short walking distance from each other. Dr. Marasco’s lab will assess metabolic and population-based changes in B cell populations of young and aged individuals post influenza vaccination, with the aim of testing the paradigm that multiple subsets of antigen-specific B cells are altered in older individuals. Conceptional innovation will be pursued by investigating both germinal center and memory origins of antigen-specific B cells, antigen-specific molecular profiling to explore the effect of immune imprinting to the critical Hemagglutinin (HA) stem epitope(s), and performing simultaneous analysis of all B cell subsets and their binding specificities to different HA epitopes. Technical innovation for this project involves functional studies with the integration of LIBRA-Seq to identify B cell subsets directed to distinct epitopes on the HA head and stem domain.
Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.
Requirements:
The funding available is for an initial appointment over three years and the starting date is flexible. The candidate will be expected to carry out bench research (both independently and as part of a team), participate in group discussions, and write research proposals and manuscripts.
Qualifications:
Those with a strong background in immunology, B cell biology, structural biology, infectious diseases and bench experience in flow cytometry and molecular biology are encouraged to apply. Background knowledge in genomics and a good knowledge of R, python and/or other programming languages is desirable, but not required. Successful candidates should demonstrate a track record of research achievements and have excellent communication skills.
Research Technician - Marasco Lab (Job ID: 2021-25366)
Description:
A lab technician position is available for a highly motivated and experienced individual who is interested in hands-on bench research in the area of therapeutic antibody discovery and engineering. This individual will be an integral member of our research team and will work with more senior members of the lab on different research projects including identifying murine/human antibodies and developing new therapies for cancer and infectious disease related applications.
As a bench scientist, this position requires basic biochemical, molecular and cell biology skills including day-to-day cell culture, molecular cloning, and various protein production/analysis techniques. There will be opportunities to participate in the development of various immunotherapies, including checkpoint modulating antibodies and CAR T cells, and to conduct biological assays to characterize these therapeutics in vitro and in vivo. Additional work includes performing literature searches, writing up methods and materials, results, figure legends and constructing figures for grant proposals, progress reports, and manuscripts.
This position also shares responsibilities for lab maintenance and operation. Applicant with 1+ years of lab experience with strong background in both molecular and cell biology techniques including production of recombinant proteins in E. coli and mammalian cells as well as subsequent biochemical and immunological analysis are preferred.
Requirements:
Description:
A lab technician position is available for a highly motivated and experienced individual who is interested in hands-on bench research in the area of therapeutic antibody discovery and engineering. This individual will be an integral member of our research team and will work with more senior members of the lab on different research projects including identifying murine/human antibodies and developing new therapies for cancer and infectious disease related applications.
As a bench scientist, this position requires basic biochemical, molecular and cell biology skills including day-to-day cell culture, molecular cloning, and various protein production/analysis techniques. There will be opportunities to participate in the development of various immunotherapies, including checkpoint modulating antibodies and CAR T cells, and to conduct biological assays to characterize these therapeutics in vitro and in vivo. Additional work includes performing literature searches, writing up methods and materials, results, figure legends and constructing figures for grant proposals, progress reports, and manuscripts.
This position also shares responsibilities for lab maintenance and operation. Applicant with 1+ years of lab experience with strong background in both molecular and cell biology techniques including production of recombinant proteins in E. coli and mammalian cells as well as subsequent biochemical and immunological analysis are preferred.
Requirements:
- Standard laboratory techniques and skills (pipetting, cell culture, PCR, plasmid prep, etc.)
- Conduct experiments, analyze experimental data and interpret results for publication
- Maintain inventory of lab supplies/reagents and contribute to maintenance and upkeep of lab equipment
- Keep a detailed notebook of all work-related activities including experimental procedures, results, and conclusions
- Contribute at an intellectual level by remaining up to date on appropriate research publications
- Present data and advances in the field to other members of the lab in both formal and informal settings
- Bachelor's Degree required with a major in biology or a related scientific field preferred
- Minimum of 1 year of related experience
- Experience in molecular biology, protein expression and purification, and cell culture is preferred
- Knowledge of techniques related to immunology, biology or infectious disease research is preferred
- Must have excellent communication skills (written and verbal) and be able to work with a wide variety of faculty and staff.
- Must be a self-starter and a highly motivated team player with excellent attention to detail
- Have the ability to analyze information and use logic to address work-related issues and problems
- Ability to work within a team environment.
Research Technician - Marasco Lab (Job ID: 2021-26156)
Description:
A lab technician position is available for a highly motivated and experienced individual who is interested in hands-on bench research in the area of viral immunology and therapeutic antibody discovery. This individual will be an integral member of our research team and will be mentored by senior members of the lab on different research projects, including identifying murine/human antibodies and developing new therapies for infectious disease related applications.
As a bench scientist, this position requires basic biochemical, molecular and cell biology skills including day-to-day cell culture, molecular cloning, various protein production/analysis techniques. There will be opportunities to contribute to research projects related to humoral cross-reactivity against influenza and COVID-19 infection, as well as the discovery of novel antibodies against Borrelia burgdorferi, the causative agent of Lyme disease. Additional work includes performing literature searches, writing up methods and materials, results, figure legends and constructing figures for grant proposals, progress reports, and manuscripts.
This position also shares responsibilities for lab maintenance and operation. Applicant with 1+ years of lab experience with strong background in both molecular and cell biology techniques including production of recombinant proteins in E. coli and mammalian cells as well as subsequent biochemical and immunological analysis are preferred.
Requirements:
Description:
A lab technician position is available for a highly motivated and experienced individual who is interested in hands-on bench research in the area of viral immunology and therapeutic antibody discovery. This individual will be an integral member of our research team and will be mentored by senior members of the lab on different research projects, including identifying murine/human antibodies and developing new therapies for infectious disease related applications.
As a bench scientist, this position requires basic biochemical, molecular and cell biology skills including day-to-day cell culture, molecular cloning, various protein production/analysis techniques. There will be opportunities to contribute to research projects related to humoral cross-reactivity against influenza and COVID-19 infection, as well as the discovery of novel antibodies against Borrelia burgdorferi, the causative agent of Lyme disease. Additional work includes performing literature searches, writing up methods and materials, results, figure legends and constructing figures for grant proposals, progress reports, and manuscripts.
This position also shares responsibilities for lab maintenance and operation. Applicant with 1+ years of lab experience with strong background in both molecular and cell biology techniques including production of recombinant proteins in E. coli and mammalian cells as well as subsequent biochemical and immunological analysis are preferred.
Requirements:
- Standard laboratory and molecular biology techniques (DNA cloning, PCR, ELISA, plasmid prep, cell culture, etc.)
- Conduct experiments, analyze experimental data and interpret results for publication
- Maintain inventory of lab supplies/reagents and contribute to maintenance and upkeep of lab equipment
- Keep a detailed notebook of all work-related activities including experimental procedures, results, and conclusions
- Contribute at an intellectual level by remaining up to date on appropriate research publications
- Present data and advances in the field to other members of the lab in both formal and informal settings
- Bachelor's Degree required with a major in biology or a related scientific field preferred
- Minimum of 1 year of related experience
- Experience in molecular biology, protein expression and purification, and cell culture is preferred
- Knowledge of techniques related to immunology, biology or infectious disease research is preferred
- Must have excellent communication skills (written and verbal) and be able to work with a wide variety of faculty and staff.
- Must be a self-starter and a highly motivated team player with excellent attention to detail
- Have the ability to analyze information and use logic to address work-related issues and problems
- Ability to work within a team environment.