JOIN US
The Marasco Lab offers exciting research opportunities in human antibody engineering and regenerative medicine. With our numerous tools including state-of-the-art humanized mouse models, we are making discoveries in B cell development, host immunity and vaccine design for both infectious disease and cancer immunotherapy applications. Our research team focuses on identification of clinically relevant human monoclonal antibodies and studies of their mechanism of action. Our humanized mouse models are also being used to investigate the pluripotency of adult stem cells with applications in the field of regenerative medicine.
Working in Dr. Marasco's laboratory provides exposure to the most recent developments in the field of antibody engineering, cancer immunotherapy, and adult stem cell biology. We are always looking for highly motivated post-doctoral fellows and graduate students to join our research team, particularly those individuals with high intellect who are also creative thinkers.
Applicants should have a strong interest in human translational research. Job openings are posted with DFCI Human Resources. Interested applicants should address their cover letter to:
Wayne A. Marasco, M.D., Ph.D.
Department of Cancer Immunology & Virology
Dana-Farber Cancer Institute
450 Brookline Avenue
Boston, MA 02215
Working in Dr. Marasco's laboratory provides exposure to the most recent developments in the field of antibody engineering, cancer immunotherapy, and adult stem cell biology. We are always looking for highly motivated post-doctoral fellows and graduate students to join our research team, particularly those individuals with high intellect who are also creative thinkers.
Applicants should have a strong interest in human translational research. Job openings are posted with DFCI Human Resources. Interested applicants should address their cover letter to:
Wayne A. Marasco, M.D., Ph.D.
Department of Cancer Immunology & Virology
Dana-Farber Cancer Institute
450 Brookline Avenue
Boston, MA 02215
Current Openings
If you are interested in joining the lab, please send your CV and cover letter to [email protected].
Scientist I - Marasco Lab (Job ID: 41320)
Our group at Dana-Farber Cancer Institute is looking for an exceptional Research Scientist to conduct research on the use of Wharton’s jelly (WJ) mesenchymal stem cells (MSC) to counter systemic inflammation and the effects of aging via a multiomics approach and humanized mouse studies.
As we age, there is a gradual increase in inflammatory markers and activation of the immune system leading to a state of chronic low-grade inflammation or “inflammaging,” which is characterized by elevated levels of pro-inflammatory cytokines, acute phase proteins, and inflammatory markers in the blood and tissues. Inflammaging is a major risk factor for age-related diseases like cardiovascular disease, cancer, Alzheimer's, arthritis, type 2 diabetes, and frailty. MSCs play a crucial role in regulating inflammation through various mechanisms and possess potent immunomodulatory properties such as the secretion of anti-inflammatory cytokines and the ability to inhibit the proliferation and function of various effector immune cells, while increasing the proliferation of regulatory T cells (Tregs) that are then able to suppress the inflammatory responses. Methods for isolating human MSCs have been well established from Wharton’s jelly and since MSC lack of expression of major histocompatibility complex (MHC) molecules and are considered as low-immunogenic, we hypothesize that transplantation of allogeneic MSC could show beneficial effects in the aged population by alleviating aging related inflammation. Our goal is to move this cellular therapy into the clinic.
Our lab at Dana-Farber Cancer Institute is seeking a motivated and experienced scientist who will contribute to discovery and translational research. The major focus of this specific position will be for a talented and committed scientist to perform serologic and molecular studies, develop and execute biological assays, interpret the results, analyze the data, and support further research activities. We are looking to expand our laboratory of creative, collaborative, yet independent thinkers, with high scientific rigor and enthusiasm who are most likely to succeed within our team. Mentorship of the candidate will focus on the development and publication of high-impact research projects and preparing the scientist for a career as an independent academic investigator or for a position in the biomedical industry.
Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned innovative researchers, dedicated clinicians and professionals, and allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients; we conduct research that advances treatment; educate tomorrow's researchers/ physician; reach out to underserved members of our community; and work with amazing partners, including other Harvard Medical School-affiliated hospitals.
Responsibilities
Our group at Dana-Farber Cancer Institute is looking for an exceptional Research Scientist to conduct research on the use of Wharton’s jelly (WJ) mesenchymal stem cells (MSC) to counter systemic inflammation and the effects of aging via a multiomics approach and humanized mouse studies.
As we age, there is a gradual increase in inflammatory markers and activation of the immune system leading to a state of chronic low-grade inflammation or “inflammaging,” which is characterized by elevated levels of pro-inflammatory cytokines, acute phase proteins, and inflammatory markers in the blood and tissues. Inflammaging is a major risk factor for age-related diseases like cardiovascular disease, cancer, Alzheimer's, arthritis, type 2 diabetes, and frailty. MSCs play a crucial role in regulating inflammation through various mechanisms and possess potent immunomodulatory properties such as the secretion of anti-inflammatory cytokines and the ability to inhibit the proliferation and function of various effector immune cells, while increasing the proliferation of regulatory T cells (Tregs) that are then able to suppress the inflammatory responses. Methods for isolating human MSCs have been well established from Wharton’s jelly and since MSC lack of expression of major histocompatibility complex (MHC) molecules and are considered as low-immunogenic, we hypothesize that transplantation of allogeneic MSC could show beneficial effects in the aged population by alleviating aging related inflammation. Our goal is to move this cellular therapy into the clinic.
Our lab at Dana-Farber Cancer Institute is seeking a motivated and experienced scientist who will contribute to discovery and translational research. The major focus of this specific position will be for a talented and committed scientist to perform serologic and molecular studies, develop and execute biological assays, interpret the results, analyze the data, and support further research activities. We are looking to expand our laboratory of creative, collaborative, yet independent thinkers, with high scientific rigor and enthusiasm who are most likely to succeed within our team. Mentorship of the candidate will focus on the development and publication of high-impact research projects and preparing the scientist for a career as an independent academic investigator or for a position in the biomedical industry.
Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned innovative researchers, dedicated clinicians and professionals, and allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients; we conduct research that advances treatment; educate tomorrow's researchers/ physician; reach out to underserved members of our community; and work with amazing partners, including other Harvard Medical School-affiliated hospitals.
Responsibilities
- Isolate (from umbilical cords) and expand human MSCs
- Test the inflammation-suppressive function of isolated human MSCs in vitro
- Confirm these results in vivo using a humanized mice model and perform advanced analytical techniques to characterize the response via transcriptome, epigenome, metabolome, and microbiome evaluation
- Maintaining accurate records, writing reports, and preparing/giving presentations.
- PhD, MD, or MD/PhD with interest in the biological sciences and significant post-doctoral research experience -or- MS with 5 years of relevant post-graduate training
- A strong background in immunology, molecular biology and cell biology
- Experience with various “omic” evaluation techniques, i.e. genomic, proteomic, transcriptomic, epigenomic, metabolomic, and microbiomic analysis
- Excellent oral and written communication skills
- Ability to perform both self-directed and guided research
- Effectively work as part of an interdisciplinary team of scientists