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The Marasco Lab offers exciting research opportunities in human antibody engineering and regenerative medicine. With our numerous tools including state-of-the-art humanized mouse models, we are making discoveries in B cell development, host immunity and vaccine design for both infectious disease and cancer immunotherapy applications. Our research team focuses on identification of clinically relevant human monoclonal antibodies and studies of their mechanism of action. Our humanized mouse models are also being used to investigate the pluripotency of adult stem cells with applications in the field of regenerative medicine.
Working in Dr. Marasco's laboratory provides exposure to the most recent developments in the field of antibody engineering, cancer immunotherapy, and adult stem cell biology. We are always looking for highly motivated post-doctoral fellows and graduate students to join our research team, particularly those individuals with high intellect who are also creative thinkers.
Applicants should have a strong interest in human translational research. Job openings are posted with DFCI Human Resources. Interested applicants should address their cover letter to:
Wayne A. Marasco, M.D., Ph.D.
Department of Cancer Immunology & Virology
Dana-Farber Cancer Institute
450 Brookline Avenue
Boston, MA 02215
Working in Dr. Marasco's laboratory provides exposure to the most recent developments in the field of antibody engineering, cancer immunotherapy, and adult stem cell biology. We are always looking for highly motivated post-doctoral fellows and graduate students to join our research team, particularly those individuals with high intellect who are also creative thinkers.
Applicants should have a strong interest in human translational research. Job openings are posted with DFCI Human Resources. Interested applicants should address their cover letter to:
Wayne A. Marasco, M.D., Ph.D.
Department of Cancer Immunology & Virology
Dana-Farber Cancer Institute
450 Brookline Avenue
Boston, MA 02215
Current Openings
If you are interested in joining the lab, please send your CV and cover letter to MarascoLab@dfci.harvard.edu.
Post-doctoral Fellow - Marasco Lab (Job ID: 2021-25412)
Overview
Our group at Dana-Farber Cancer Institute is looking for exceptional Post-doctoral Fellow to conduct research in an area of Tick-borne infectious diseases, specifically Lyme Disease. This is an inter-institutional collaborative project involving MIT, Whitehead Institute, Tufts and Dana-Farber Cancer Institute.
The project builds on field studies in which researchers partially vaccinated populations of the white-footed mouse with the outer surface protein A (Osp A) from B. burgdorferi and found that these mice play a critical role in controlling high levels of the Lyme pathogen in the environment. We plan to engineer white-footed mice to carry multiple copies of anti-Osp A neutralizing antibodies against B. burgdorfei, in hopes of disrupting the transmission cycles for decades, substantially reducing the total number of infected ticks and the risk of human exposure.
Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned innovative researchers, dedicated clinicians and professionals, and allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients; we conduct research that advances treatment; educate tomorrow's researchers/ physician; reach out to underserved members of our community; and work with amazing partners, including other Harvard Medical School-affiliated hospitals.
Requirements
Our lab at Dana-Farber Cancer Institute is seeking a motivated and talented scientist who will contribute to discovery and translational research. The major focus of this specific position will be for a very talented and committed scientist to perform antibody discovery and cellular engineering, develop and execute biological assays, interpret the results, analyze the data, and support further research activities. We are looking to expand our laboratory of creative, collaborative, yet independent thinkers, with high scientific rigor and enthusiasm who are most likely to succeed within our team. Mentorship of the candidate will focus on the development and publication of high-impact research projects and preparing the fellow for a career as an independent academic investigator or for a position in the biomedical industry.
Specific responsibilities include:
Overview
Our group at Dana-Farber Cancer Institute is looking for exceptional Post-doctoral Fellow to conduct research in an area of Tick-borne infectious diseases, specifically Lyme Disease. This is an inter-institutional collaborative project involving MIT, Whitehead Institute, Tufts and Dana-Farber Cancer Institute.
The project builds on field studies in which researchers partially vaccinated populations of the white-footed mouse with the outer surface protein A (Osp A) from B. burgdorferi and found that these mice play a critical role in controlling high levels of the Lyme pathogen in the environment. We plan to engineer white-footed mice to carry multiple copies of anti-Osp A neutralizing antibodies against B. burgdorfei, in hopes of disrupting the transmission cycles for decades, substantially reducing the total number of infected ticks and the risk of human exposure.
Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned innovative researchers, dedicated clinicians and professionals, and allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients; we conduct research that advances treatment; educate tomorrow's researchers/ physician; reach out to underserved members of our community; and work with amazing partners, including other Harvard Medical School-affiliated hospitals.
Requirements
Our lab at Dana-Farber Cancer Institute is seeking a motivated and talented scientist who will contribute to discovery and translational research. The major focus of this specific position will be for a very talented and committed scientist to perform antibody discovery and cellular engineering, develop and execute biological assays, interpret the results, analyze the data, and support further research activities. We are looking to expand our laboratory of creative, collaborative, yet independent thinkers, with high scientific rigor and enthusiasm who are most likely to succeed within our team. Mentorship of the candidate will focus on the development and publication of high-impact research projects and preparing the fellow for a career as an independent academic investigator or for a position in the biomedical industry.
Specific responsibilities include:
- Conducting cell-based and molecular biology research aimed at isolating immune B cells from immunized mice for the eventual discovery of anti-Osp A monoclonal antibodies (mAbs). Our laboratory utilizes several technologies to isolate these mAb including single cell plasmablast and/or memory B cells cloning as well as use of phage and yeast display platforms.
- Production and characterization of these mAbs for epitope binning, kinetic binding measurements and neutralization activity
- Performing preclinical studies in mouse models Lyme disease.
- Maintaining accurate records, writing reports, and preparing/giving presentations.
- PhD, MD, or MD/PhD with interest in the biological sciences
- A strong background in immunology, molecular biology and cell biology
- Excellent oral and written communication skills
- Ability to perform both self-directed and guided research
- Effectively work as part of an interdisciplinary team of scientists
Research Technician - Marasco Lab (Job ID: 2021-25366)
Description:
A lab technician position is available for a highly motivated and experienced individual who is interested in hands-on bench research in the area of therapeutic antibody discovery and engineering. This individual will be an integral member of our research team and will work with more senior members of the lab on different research projects including identifying murine/human antibodies and developing new therapies for cancer and infectious disease related applications.
As a bench scientist, this position requires basic biochemical, molecular and cell biology skills including day-to-day cell culture, molecular cloning, and various protein production/analysis techniques. There will be opportunities to participate in the development of various immunotherapies, including checkpoint modulating antibodies and CAR T cells, and to conduct biological assays to characterize these therapeutics in vitro and in vivo. Additional work includes performing literature searches, writing up methods and materials, results, figure legends and constructing figures for grant proposals, progress reports, and manuscripts.
This position also shares responsibilities for lab maintenance and operation. Applicant with 1+ years of lab experience with strong background in both molecular and cell biology techniques including production of recombinant proteins in E. coli and mammalian cells as well as subsequent biochemical and immunological analysis are preferred.
Requirements:
Description:
A lab technician position is available for a highly motivated and experienced individual who is interested in hands-on bench research in the area of therapeutic antibody discovery and engineering. This individual will be an integral member of our research team and will work with more senior members of the lab on different research projects including identifying murine/human antibodies and developing new therapies for cancer and infectious disease related applications.
As a bench scientist, this position requires basic biochemical, molecular and cell biology skills including day-to-day cell culture, molecular cloning, and various protein production/analysis techniques. There will be opportunities to participate in the development of various immunotherapies, including checkpoint modulating antibodies and CAR T cells, and to conduct biological assays to characterize these therapeutics in vitro and in vivo. Additional work includes performing literature searches, writing up methods and materials, results, figure legends and constructing figures for grant proposals, progress reports, and manuscripts.
This position also shares responsibilities for lab maintenance and operation. Applicant with 1+ years of lab experience with strong background in both molecular and cell biology techniques including production of recombinant proteins in E. coli and mammalian cells as well as subsequent biochemical and immunological analysis are preferred.
Requirements:
- Standard laboratory techniques and skills (pipetting, cell culture, PCR, plasmid prep, etc.)
- Conduct experiments, analyze experimental data and interpret results for publication
- Maintain inventory of lab supplies/reagents and contribute to maintenance and upkeep of lab equipment
- Keep a detailed notebook of all work-related activities including experimental procedures, results, and conclusions
- Contribute at an intellectual level by remaining up to date on appropriate research publications
- Present data and advances in the field to other members of the lab in both formal and informal settings
- Bachelor's Degree required with a major in biology or a related scientific field preferred
- Minimum of 1 year of related experience
- Experience in molecular biology, protein expression and purification, and cell culture is preferred
- Knowledge of techniques related to immunology, biology or infectious disease research is preferred
- Must have excellent communication skills (written and verbal) and be able to work with a wide variety of faculty and staff.
- Must be a self-starter and a highly motivated team player with excellent attention to detail
- Have the ability to analyze information and use logic to address work-related issues and problems
- Ability to work within a team environment.